I’ve had my AxeFX2+ for about a year now. I’ve found that the best starting point for working on ANY kind of tone is to start, of course, with the Amp and Cab models, and the VERY FIRST thing to do is “fix” the cabinet model with high and low pass filtering. This can all be done within the cab block. The low-pass filter is not as important as the high-pass filter.
To explain: a high-pass filter will ALLOW all frequencies ABOVE the threshold you set, and BLOCK all frequencies below it.
When an engineer records guitars for an album or demo, they use frequency ranges for each instrument. A VERY solid rule is that your guitar tone should start between 100 and 120 Hz. Everything below that belongs to bass instruments (bass guitar, kick drum, left-hand keys). That said, set that high-pass filter to 100 Hz with a hard cut, and start building tone from there, including the rest of the cab stuff, like Mic selection, etc.
Get the tone from the amp before you move on to any effects. Like all situations, unless you have a specific need (or style) keep effect levels low. Leave more organic tone intact.