Yes there is a plug in that can completely isolate guitar track or other audio sound however they are complicated to use and also they are very expansive. Like really, one of my teacher uses one and gave us the example that he used it to clean up audio footage for a court case. Mind you that he runs a studio professionally. He knows what he's doing.
And yeah I mean, if you want to hear the guitar more clearly, you can always play with the EQ and try to cut as much as you can while trying to keep the guitar clean. I mean, you're not going to have a crystal clear guitar track but that just might do the trick for what you need it! Basically what Ids said, you'll mostly find the guitar in the mid range so yeah!
Other than that there is the classic ''Karaoke'' cutting vocals technique that could make the guitars more audible but its still not a fully clean technique or other different mixing technique that im not fully familiar with that can help cancel out some tracks and make the guitar more audible