I would say if you have to droptune, get a Digitech The Drop or Digitech Whammy TD, very useful
If you have an FX loop, put a volume pedal before reverb, delay, chorus, phaser… Like that you can cut your sound, but still have reverb and delay running, lot more realistic.
But that’s hard to tell, it must reflect your playstyle and how you use your stuff, in my case I wouldn’t use a sustain but a boost (something like +12 dB) for my solos (soli ?), noise gate and EQ in the loop to boost up frequencies lost in my NG